بررسی رابطه نشانگرهای التهابی و شدت بیماری عروق کرونر

Background and purpose: Coronary heart disease is one of the main causes of death and disability in human society. Nowadays, one of the ways of identifying the risk factors is to examine the inflammatory markers. The purpose of this research was to study the relation of inflammatory markers with the intensity of coronary involvement, which is distinguished through angiography. Materials and Methods: In this cross sectional-analytical study 200 patients, whom undergone angiography at Mazandaran Heart Center during 2004-5, were recruited. The intensity of the coronary heart involvement was determined based on angiography or the number of involved vessels and the intensity of vessel narrowness. The patients were then divided into two groups: high risk and low risk. The patients’ information was recorded in a questionnaire and in order to study the inflammatory markers, their blood was sampled to measure WBC, platelet, ESR and CRP. Data were analyzed using T and chi-square tests, in SPSS version 11. Results: One hundred and fifty seven (%78.5) out of the 200 patients were men Ninty four patients (%47) were put in high risk group and 106 (%53) in low risk group. There was no significant relationship between gender, job, body mass index, education, duration of heart disease, suffering from diabetis mellitus, dyslipidemia, smoking, the number of WBC, platelet and ESR with the intensity of coronary heart disease. Patients of high risk group attended the hospital more frequently than low risk group, because of heart disease (P=%24) and that the amount of CRP in these patients was more than the low risk group significantly (P=%47). Conclusion: Regarding the inflammatory markers, it seems that only CRP has a relationship with the intensity of the coronary involvement. More studies for examining the causes, effects and suggesting interventions for the control of the condition seem to be necessary.